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Small vessel cerebrovascular disease

MedGen UID:
453310
Concept ID:
C2733158
Disease or Syndrome
Synonyms: Cerebral Microangiopathies; Cerebral Microangiopathy; Cerebral Small Vessel Disease; Cerebral Small Vessel Diseases; Microangiopathies, Cerebral; Microangiopathy, Cerebral
SNOMED CT: Cerebral small vessel disease (443929000); Small vessel cerebrovascular disease (443929000)

Definition

Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE. [from MeSH]

Professional guidelines

PubMed

Armario P, Avellaneda-Gómez C, Gómez-Choco M
Arch Bronconeumol 2024 Feb;60(2):77-79. Epub 2023 Nov 23 doi: 10.1016/j.arbres.2023.11.014. PMID: 38052680

Recent clinical studies

Etiology

Morales CD, Cotton-Samuel D, Lao PJ, Chang JF, Pyne JD, Alshikho MJ, Lippert RV, Bista K, Hale C, Edwards NC, Igwe KC, Deters K, Zimmerman ME, Brickman AM
Alzheimers Res Ther 2024 Feb 2;16(1):25. doi: 10.1186/s13195-024-01395-x. PMID: 38308344Free PMC Article
Bir SC, Khan MW, Javalkar V, Toledo EG, Kelley RE
J Stroke Cerebrovasc Dis 2021 Aug;30(8):105864. Epub 2021 May 29 doi: 10.1016/j.jstrokecerebrovasdis.2021.105864. PMID: 34062312
Stamm BC, Lao PJ, Rizvi B, Colon J, Igwe K, Chesebro AG, Maas B, Schupf N, Mayeux R, Manly JJ, Brickman AM
J Gerontol A Biol Sci Med Sci 2020 Oct 15;75(11):2156-2161. doi: 10.1093/gerona/glz291. PMID: 31838489Free PMC Article
MacEwen C, Watkinson P, Tarassenko L, Pugh C
Semin Dial 2018 May;31(3):199-203. Epub 2018 Feb 11 doi: 10.1111/sdi.12679. PMID: 29430730
Menon U, Kelley RE
Int Rev Neurobiol 2009;84:21-33. doi: 10.1016/S0074-7742(09)00402-4. PMID: 19501711

Diagnosis

Armario P, Avellaneda-Gómez C, Gómez-Choco M
Arch Bronconeumol 2024 Feb;60(2):77-79. Epub 2023 Nov 23 doi: 10.1016/j.arbres.2023.11.014. PMID: 38052680
Bir SC, Khan MW, Javalkar V, Toledo EG, Kelley RE
J Stroke Cerebrovasc Dis 2021 Aug;30(8):105864. Epub 2021 May 29 doi: 10.1016/j.jstrokecerebrovasdis.2021.105864. PMID: 34062312
Soldan A, Pettigrew C, Zhu Y, Wang MC, Gottesman RF, DeCarli C, Albert M; BIOCARD Research Team
Ann Clin Transl Neurol 2020 Aug;7(8):1307-1317. Epub 2020 Jul 21 doi: 10.1002/acn3.51120. PMID: 32856790Free PMC Article
Pettigrew C, Soldan A, Zhu Y, Cai Q, Wang MC, Moghekar A, Miller MI, Singh B, Martinez O, Fletcher E, DeCarli C, Albert M
Neurobiol Aging 2020 Apr;88:33-41. Epub 2019 Dec 17 doi: 10.1016/j.neurobiolaging.2019.12.003. PMID: 31932050Free PMC Article
Brickman AM
Curr Neurol Neurosci Rep 2013 Dec;13(12):415. doi: 10.1007/s11910-013-0415-7. PMID: 24190781Free PMC Article

Therapy

Morales CD, Cotton-Samuel D, Lao PJ, Chang JF, Pyne JD, Alshikho MJ, Lippert RV, Bista K, Hale C, Edwards NC, Igwe KC, Deters K, Zimmerman ME, Brickman AM
Alzheimers Res Ther 2024 Feb 2;16(1):25. doi: 10.1186/s13195-024-01395-x. PMID: 38308344Free PMC Article
Shou B, Chen X, Hou Y
Int J Psychiatry Med 2024 Sep;59(5):556-568. Epub 2024 Jan 17 doi: 10.1177/00912174241227513. PMID: 38233080
Yatawara C, Zailan FZ, Chua EV, Lim LLH, Silva E, Wang JS, Ng A, Ng KP, Kandiah N
Clin Interv Aging 2021;16:301-309. Epub 2021 Feb 19 doi: 10.2147/CIA.S290055. PMID: 33642856Free PMC Article
MacEwen C, Watkinson P, Tarassenko L, Pugh C
Semin Dial 2018 May;31(3):199-203. Epub 2018 Feb 11 doi: 10.1111/sdi.12679. PMID: 29430730
Cahn-Weiner DA, Farias ST, Julian L, Harvey DJ, Kramer JH, Reed BR, Mungas D, Wetzel M, Chui H
J Int Neuropsychol Soc 2007 Sep;13(5):747-57. Epub 2007 May 18 doi: 10.1017/S1355617707070853. PMID: 17521485Free PMC Article

Prognosis

Morales CD, Cotton-Samuel D, Lao PJ, Chang JF, Pyne JD, Alshikho MJ, Lippert RV, Bista K, Hale C, Edwards NC, Igwe KC, Deters K, Zimmerman ME, Brickman AM
Alzheimers Res Ther 2024 Feb 2;16(1):25. doi: 10.1186/s13195-024-01395-x. PMID: 38308344Free PMC Article
Otoki Y, Yu D, Shen Q, Sahlas DJ, Ramirez J, Gao F, Masellis M, Swartz RH, Chan PC, Pettersen JA, Kato S, Nakagawa K, Black SE, Swardfager W, Taha AY
J Alzheimers Dis 2023;93(2):665-682. doi: 10.3233/JAD-220795. PMID: 37092220
Bir SC, Khan MW, Javalkar V, Toledo EG, Kelley RE
J Stroke Cerebrovasc Dis 2021 Aug;30(8):105864. Epub 2021 May 29 doi: 10.1016/j.jstrokecerebrovasdis.2021.105864. PMID: 34062312
Stösser S, Böckler S, Ludolph AC, Kassubek J, Neugebauer H
J Neurol 2019 May;266(5):1230-1235. Epub 2019 Feb 26 doi: 10.1007/s00415-019-09253-9. PMID: 30806767
MacEwen C, Watkinson P, Tarassenko L, Pugh C
Semin Dial 2018 May;31(3):199-203. Epub 2018 Feb 11 doi: 10.1111/sdi.12679. PMID: 29430730

Clinical prediction guides

Morales CD, Cotton-Samuel D, Lao PJ, Chang JF, Pyne JD, Alshikho MJ, Lippert RV, Bista K, Hale C, Edwards NC, Igwe KC, Deters K, Zimmerman ME, Brickman AM
Alzheimers Res Ther 2024 Feb 2;16(1):25. doi: 10.1186/s13195-024-01395-x. PMID: 38308344Free PMC Article
Otoki Y, Yu D, Shen Q, Sahlas DJ, Ramirez J, Gao F, Masellis M, Swartz RH, Chan PC, Pettersen JA, Kato S, Nakagawa K, Black SE, Swardfager W, Taha AY
J Alzheimers Dis 2023;93(2):665-682. doi: 10.3233/JAD-220795. PMID: 37092220
Saleh Y, Le Heron C, Petitet P, Veldsman M, Drew D, Plant O, Schulz U, Sen A, Rothwell PM, Manohar S, Husain M
Brain 2021 May 7;144(4):1247-1262. doi: 10.1093/brain/awab013. PMID: 33734344Free PMC Article
Soldan A, Pettigrew C, Zhu Y, Wang MC, Gottesman RF, DeCarli C, Albert M; BIOCARD Research Team
Ann Clin Transl Neurol 2020 Aug;7(8):1307-1317. Epub 2020 Jul 21 doi: 10.1002/acn3.51120. PMID: 32856790Free PMC Article
Stösser S, Böckler S, Ludolph AC, Kassubek J, Neugebauer H
J Neurol 2019 May;266(5):1230-1235. Epub 2019 Feb 26 doi: 10.1007/s00415-019-09253-9. PMID: 30806767

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